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Stephen Poole Selected Research

TGN-1412 (TGN1412)

8/2013Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.
8/2011Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy.
7/2011Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture.
12/2009Safety of biologics, lessons learnt from TGN1412.
9/2007"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.

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Stephen Poole Research Topics

Disease

13Pain (Aches)
05/2010 - 03/2002
12Fever (Fevers)
01/2022 - 10/2004
11Hyperalgesia
11/2009 - 03/2002
10Inflammation (Inflammations)
07/2014 - 03/2002
6Necrosis
08/2011 - 02/2002
5Cytokine Release Syndrome
08/2013 - 09/2007
5Anorexia
06/2011 - 02/2002
5Neuralgia (Stump Neuralgia)
05/2010 - 02/2003
4COVID-19
04/2022 - 10/2020
4Human Influenza (Influenza)
01/2022 - 01/2014
4Hypersensitivity (Allergy)
11/2008 - 03/2002
3Infections
01/2021 - 11/2006
2Virus Diseases (Viral Diseases)
04/2022 - 10/2004
2Hypothermia
07/2014 - 07/2008
2Cardiovascular Diseases (Cardiovascular Disease)
02/2014 - 06/2005
1Pneumonia (Pneumonitis)
04/2022
1Viral Pneumonia
04/2022
1Communicable Diseases (Infectious Diseases)
02/2021
1Alzheimer Disease (Alzheimer's Disease)
01/2016
1Parkinson Disease (Parkinson's Disease)
01/2016
1Influenza in Birds (Avian Flu)
01/2014
1Amyloidosis
10/2012
1Acute-Phase Reaction
10/2012
1Psychotic Disorders (Schizoaffective Disorder)
07/2012
1Fatigue
07/2011
1Lethargy
06/2011
1Lung Diseases (Lung Disease)
05/2010
1Fibrosis (Cirrhosis)
05/2010
1Asthma (Bronchial Asthma)
05/2010

Drug/Important Bio-Agent (IBA)

25CytokinesIBA
01/2022 - 03/2002
15Interleukin-6 (Interleukin 6)IBA
07/2014 - 03/2002
13Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2014 - 03/2002
9InterleukinsIBA
07/2014 - 01/2003
7Interleukin-10 (Interleukin 10)IBA
07/2014 - 04/2002
6LipopolysaccharidesIBA
07/2014 - 11/2004
6Interleukin-1 (Interleukin 1)IBA
07/2007 - 02/2002
5TGN-1412 (TGN1412)IBA
08/2013 - 09/2007
5AntibodiesIBA
08/2011 - 02/2002
4Proteins (Proteins, Gene)FDA Link
10/2020 - 03/2002
4Dinoprostone (PGE2)FDA Link
07/2014 - 03/2002
4LeptinIBA
07/2012 - 11/2004
4Interleukin-1beta (Interleukin 1 beta)IBA
08/2008 - 03/2002
4Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
07/2008 - 07/2003
4Atenolol (Tenormin)FDA LinkGeneric
11/2005 - 03/2002
4Indomethacin (Indometacin)FDA LinkGeneric
11/2005 - 03/2002
3Antiviral Agents (Antivirals)IBA
01/2022 - 10/2020
3AcidsIBA
01/2014 - 02/2002
3ProstaglandinsIBA
06/2011 - 07/2003
3ChemokinesIBA
11/2008 - 10/2006
3AntigensIBA
11/2008 - 07/2003
3PyrogensIBA
11/2006 - 03/2003
2Pharmaceutical PreparationsIBA
01/2022 - 07/2008
2Immunoglobulins (Immunoglobulin)IBA
01/2022 - 03/2002
2Neuraminidase (Sialidase)IBA
01/2021 - 12/2019
2Biomarkers (Surrogate Marker)IBA
01/2021 - 01/2016
2Anti-Bacterial Agents (Antibiotics)IBA
12/2019 - 03/2002
2C-Reactive ProteinIBA
02/2014 - 10/2012
2TurpentineIBA
07/2012 - 08/2007
2Dopamine (Intropin)FDA LinkGeneric
07/2012 - 03/2002
2Morphine (MS Contin)FDA LinkGeneric
11/2008 - 11/2005
2Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
08/2007 - 02/2002
2Immune Sera (Antisera)IBA
09/2006 - 10/2002
2MK-886IBA
11/2005 - 07/2003
25-Lipoxygenase-Activating ProteinsIBA
11/2005 - 07/2003
2Dexamethasone (Maxidex)FDA LinkGeneric
11/2005 - 07/2003
2EndotoxinsIBA
03/2005 - 11/2004
2Pentoxifylline (Trental)FDA LinkGeneric
12/2004 - 07/2003
2Interleukin-8 (Interleukin 8)IBA
07/2003 - 03/2002
2AminesIBA
07/2003 - 03/2002
2CP 105696IBA
07/2003 - 04/2002
2Sympathomimetics (Sympathomimetic Amines)IBA
10/2002 - 03/2002
1Nucleosomes (Nucleosome)IBA
01/2022
1VaccinesIBA
01/2022
1AdrenomedullinIBA
01/2021
1proadrenomedullinIBA
01/2021
1alpha-SynucleinIBA
01/2016
1Hemagglutinins (Hemagglutinin)IBA
01/2014
1Single-Domain AntibodiesIBA
01/2014
1Interleukin-2 (IL2)IBA
08/2013
1Serum Amyloid P-ComponentIBA
10/2012
1Blood Proteins (Serum Proteins)IBA
10/2012
1Alemtuzumab (Campath)FDA Link
08/2011
1Trastuzumab (Herceptin)FDA Link
08/2011
1Monoclonal AntibodiesIBA
07/2011
1Diclofenac (SR 38)FDA LinkGeneric
06/2011
1interleukin-1beta-converting enzyme inhibitorIBA
06/2011
1DNA (Deoxyribonucleic Acid)IBA
05/2010
1Interleukin-13IBA
05/2010
12- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosineIBA
11/2009
1Adenosine (Adenocard)FDA LinkGeneric
11/2009
1ATL 313IBA
11/2009

Therapy/Procedure

5Therapeutics
11/2009 - 03/2002
3Intraperitoneal Injections
07/2008 - 10/2004
2Transurethral Resection of Prostate (TURP)
07/2012 - 08/2007
2Aftercare (After-Treatment)
11/2006 - 11/2004
1Critical Care (Surgical Intensive Care)
04/2022
1Drug Therapy (Chemotherapy)
02/2021
1Length of Stay
12/2019
1Immunotherapy
01/2014
1Cardiopulmonary Resuscitation (CPR)
07/2011